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    Micro Crystalline Cellulose
    
    
    Micro Crystalline Cellulose is a mechanically
    disintegrated level of D.P. Cellulose. It comprises purified,
    de-polymerised, Micro Crystalline sub micron size colloidal particles. It is
    produced by treating Alfa Cellulose obtained as a pulp from fibrous plants
    with minerals acid. 
     
     It is a white, odourless, tasteless, extra free flowing powder which is
    relatively free from organic and non-organic contaminants. It is
    metabolically inert, and has excellent water absorptive, swelling &
    dispersion properties, is insoluble in water, dilute acid, common organic
    solvents and oils. It is partially soluble in dilute alkali. 
 
    Brand 
    Micro Crystalline Cellulose is offered in ordinary
    non spray dried & spray dried directly compressible forms under the
    brand name LIBRAWCEL
    Process
    Rayon Grade wood pulp, the main raw material is
    hydrolyzed under very carefully controlled conditions. After Hydrolysis,
    specific inclusion of hydrophobic agents is done. This is followed by
    thorogh washing with de-mineralised water. The depathogenised slurry
    prepared is pumped for Spray Drying and finally blended and packed. 
    Spray Drying
    For the first time in India, Spray Dried Micro
    Crystalline Cellulose is being manufactured & offered to the customer at
    competitive prices. The Spray drier has been supplied and installed by M/s.
    ALFA Laval in technical collaboration with APV Pasilac Anhydro, A/S Denmark.
     
     The atomization of the feed to be dried takes place concurrent to the
    drying air in a very robust atomizer revolving at an ultra high speed. The
    profile of temperatures in the drier can be adjusted to give optimum drying
    conditions. The feed to the atomizer is governed automatically by the
    temperature of the air. The powder is collected at two points. 
    Direct Compressible Grade 
    Librawcel, Direct Compressible Grade of Micro
    Crystalline Cellulose can be compressed into self - binding tablets, a boon
    for tablets manufacturers. 
    Advantages
    Direct Compressible Grade of Micro Crystalline
    cellulose performs as an excipient to assist in the flow, lubrication and
    binding properties of the ingredients to be tableted and improves stability
    of durgs. Facilitate rapid disintegration of the tablet. It can be used in
    direct compression of most drugs and because of savings in material,
    capital, equipment and labour, it compensates the higher price of Direct
    Compressible Micro Crystalline Cellulose over non spray dried Micro
    Crystalline Cellulose. 
     
     The conventional costly method of tableting through 6 process steps is
    replaced by 2 steps direct compression method of tableting. Detailed tests
    and investigations by various agencies for the use of Direct Compressible
    Grade Micro Crystalline Cellulose powder in tableting have shown :
    
      - Excellent Compression & Hardness
 
      - No Sign of Lubrication Difficulties 
 
      - Good Flowing Properties 
 
      - Reduces Friability & Weight Loss
 
    
 
    Librawcel Standards 
    
      
          | 
        
        
          
            | Particle Size /
            Moisture Content | 
           
          
            | Grade | 
            Particle Size Standards  | 
            Average Particle Size  | 
            Moisture | 
           
          
            | Librawcel 101 | 
            +60 Mesh Not more than 1% 
             +200 Mesh Less than 30% | 
            50 Micron  | 
            5 | 
           
          
            | Librawcel 102 | 
            +60 Mesh Not more than 8% 
             +200 Mesh Less than 45% | 
            100 Micron | 
            5 | 
           
          
            | Librawcel 103 | 
            +60 Mesh Not more than 1% 
             +200 Mesh Less than 30% | 
            50 Micron  | 
            3 | 
           
          | 
          | 
      
    
    
    
    
      
          | 
        
        
          
            | Microbiological
            Analysis | 
           
          
            | A | 
            Total microbial count
            - NMT 100 CFU | 
           
          
            | B | 
            Staphylococuus aureus
            negative | 
           
          
            | C | 
            Salmonella species
            negative | 
           
          
            | D | 
            E. coli negative | 
           
          | 
          | 
      
    
    
     
    
    Comparison chart of Specificatoins
    
      
          | 
        
        
          
            | Specifications | 
            I.P. | 
            U.S.P. | 
            B.P. | 
            Librawcel Average 
             Analysis Result  | 
           
          
            | Tests | 
           
          
            | Identificatoin | 
            To Comply | 
            To Comply | 
            To Comply | 
            To Comply USP | 
           
          
            | PH | 
            5.0 to 7.0 | 
            5.5 to 7.0 | 
            5.0 - 7.5 | 
            5.8 to 6.5 | 
           
          
            | Loss on Drying | 
            NMT 5% | 
            NMT 5% | 
            NMT 6% | 
            3.5 - 4.0 | 
           
          
            | Water Soluble Substances | 
            Max. 0.16% | 
            Max. 0.16% | 
            Max. 0.2% | 
            Max. 0.12% | 
           
          
            | Residue on ignition | 
            NMT 0.2% | 
            NMT 0.05% | 
            NMT 0.1% | 
            Max. 0.05% | 
           
          
            | Heavy metals | 
            NMT 10ppm | 
            NMT 10ppm | 
            NMT 10ppm | 
            Max. 10ppm | 
           
          
            | Starch | 
            Negative | 
            Negative | 
            Negative | 
            Negative | 
           
          
            | Arsenic | 
            NMT 2ppm | 
            NMT 2ppm | 
            NMT 2ppm | 
            NMT 2ppm | 
           
          
            | Assay | 
            97 - 102% | 
            91 - 102% | 
            91 - 102% | 
            98.5 - 100% | 
           
          | 
          | 
      
    
    
     
    
    Quality Control
    At Libraw, we believe in offering quality products
    at affordable prices. Precautions are taken right from the sourcing of raw
    material to the final packaging. The procurement of raw material is
    subjected to intense quality check before being accepted. We have an inbuilt
    system of analyzing the quality at various levels of production to ensure a
    consistent superior product. We have a very elaborate modern sophisticated
    laboratory where the final product is analysed for the detailed 
    specification before it is cleared for despatch.
    Microbiological Laboratory
    Libraw Pharma has a modern Micro Biological
    Laboratory to conduct micro biological tests essential to make hygienic
    products. 
    Packing
    Packing is done in pre laminated HDPE bags. Any
    modifications in packing can be suited to the customer need. Librawcel is
    developed for the pharmaceutical industry where it has found extensive use
    as an excipient and diluent. It has replaced competitive products because of
    its uniqueness. For instance - In tableting, Starch is a good disintegrate
    but a poor binder; Lactose is a good binder but a poor disintegrant. Spray
    Dried Micro Crystalline Cellulose is an excellent binder and a good
    disintegrant.
     
     Non Spray Dried Micro Crystalline Cellulose, though less expensive than
    Spray Dried Micro Crystalline Cellulose, is less pure and has poor flow
    properties. In some pharmaceutical tablet products, traces of inorganic
    impurities can markedly reduce drug stability and shelf life. 
    Librawcel - 102 Microcrystalline Cellulose, IP (Spray
    Dried)
    
      
          | 
        
        
          
            | Parameters | 
            Specification | 
            Result | 
           
          
            | Description | 
            Fine or Granular, White or almost
            White, Free flowing Powder, Odorless | 
            Free flowing, White powder
            Odorless | 
           
          
            | Solubility | 
            Insoluble in water slight soluble
            in dil. Sodium Hydroxide solution. It is insoluble in dil. Acids and
            most organic solvents. | 
            Complies | 
           
          
            | Identification | 
           
          
            | A | 
            Should comply | 
            Complies | 
           
          
            | B | 
            Should comply | 
            Complies | 
           
          
            | C | 
            Should comply | 
            Complies | 
           
          
            | pH | 
            5 to 7.5 | 
            6.21 | 
           
          
            | Starch and Dextrins | 
            Absent | 
            Absent | 
           
          
            | Organic Impurities | 
            Should Comply | 
            Complies | 
           
          
            | Water Soluble Substances % | 
            NMT 0.2 | 
            0.14 | 
           
          
            | Arsenic, ppm | 
            NMT 2 | 
            Passes | 
           
          
            | Heavy Metal, ppm | 
            NMT 10 | 
            Passes | 
           
          
            | Sulphated Ash, % | 
            NMT 0.2 | 
            0.063 | 
           
          
            | Loss on Drying % | 
            NMT 6 | 
            4 | 
           
          
            | Assay, % Cellulose | 
            97 - 102 | 
            99.42 | 
           
          
            | In-House
            Specification* | 
           
          
            | Particle Size % | 
           
          
            | Wt. + 60 mesh | 
            NMT 8 | 
            Passes | 
           
          
            | Wt. +200 mesh | 
            NLT 45 | 
            Passes | 
           
          | 
          | 
      
    
    
     
    
    Librawcel - W Microcrystalline Cellulose, IP (Bulk
    Dried)
    
      
          | 
        
        
          
            | Parameters | 
            Specification | 
            Result | 
           
          
            | Description | 
            Fine or Granular, White or almost
            White, Odorless | 
            Fine, White, Odorless Powder
            Complies | 
           
          
            | Solubility | 
            Insoluble in water slight soluble
            in dil. Sodium Hydroxide solution,insoluble in dil. Acids and most
            organic solvents & soluble in ammoniacal solution of copper
            tetra mine. | 
             | 
           
          
            | Indentification A, B & C | 
            Should comply | 
            Complies | 
           
          
            | B Degree of Polymerizatoin | 
            NMT 350 | 
            195 | 
           
          
            | pH | 
            5 to 7.5 | 
            6.39 | 
           
          
            | Starch and Dextrins | 
            Absent  | 
            Absent  | 
           
          
            | Organic Impurities | 
            Should Comply | 
            Complies | 
           
          
            | Water Soluble Substances % | 
            NMT 0.2 | 
            0.1 | 
           
          
            | Ether Soluble Sbustances | 
            NMT0.05 | 
            0.02 | 
           
          
            | Arsenic, ppm | 
            NMT 2 | 
            Passes | 
           
          
            | Heavy Metal, ppm | 
            NMT 10 | 
            Passes | 
           
          
            | Sulphated Ash, % | 
            NMT 0.1 | 
            0.072 | 
           
          
            | Loss on Drying % | 
            NMT 6 | 
            3.6 | 
           
          
            | Assay, % Cellulose | 
            97 - 102 | 
            99.7 | 
           
          
            | In-House
            Specification* | 
           
          
            | Particle Size % | 
           
          
            | Wt. + 60 mesh | 
            NMT 1 | 
            Passes | 
           
          
            | Wt. +200 mesh | 
            NLT 30 | 
            Passes | 
           
          | 
          |